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Do older individuals who are diagnosed with cancer have worse physical performance prior to diagnosis compared to matched controls? A longitudinal cohort study.

Identifieur interne : 000F54 ( Main/Exploration ); précédent : 000F53; suivant : 000F55

Do older individuals who are diagnosed with cancer have worse physical performance prior to diagnosis compared to matched controls? A longitudinal cohort study.

Auteurs : S M L M. Looijaard [Pays-Bas] ; M S Slee-Valentijn [Pays-Bas] ; L N Groeneveldt [Pays-Bas] ; D J H. Deeg [Pays-Bas] ; M. Huisman [Pays-Bas] ; A B Maier [Pays-Bas, Australie]

Source :

RBID : pubmed:30021524

Descripteurs français

English descriptors

Abstract

BACKGROUND

Impaired physical performance is highly prevalent in older cancer patients and is associated with cancer-related outcomes such as mortality and chemotherapy-related toxicity. Physical performance might already decline prior to the cancer diagnosis due to undiagnosed disease. This study aimed to assess whether the physical performance of community-dwelling individuals prior to cancer diagnosis is worse compared to matched controls who are not diagnosed with cancer.

METHODS

The study sample was selected from the Longitudinal Aging Study Amsterdam, a longitudinal study on a nationally representative sample of the Dutch older population. Physical performance of initially cancer-free individuals aged 55-84 years who were diagnosed with cancer during 10 or 20 years of follow-up was compared to the physical performance of controls who were not diagnosed with cancer. For controls, the physical performance measurements of the cycle with a median age closest to the cancer group were used. The time interval between physical performance measurements and the report of cancer was 2 to 4 years. Groups were compared using logistic and linear regression analysis.

RESULTS

The study sample included 1735 individuals with a median age of 68.7 [interquartile range 63.3-76.4] years. During follow-up, 414 (23.9%) individuals were diagnosed with cancer. Handgrip strength, gait speed, chair stand ability, chair stand test time and ability to put on and take off a cardigan did not differ between groups. Individuals prior to cancer diagnosis were more likely to complete the tandem balance test.

CONCLUSIONS

Physical performance of individuals 2 to 4 years prior to report of cancer diagnosis is not lower compared to controls. This suggests that physical performance may not be influenced by cancer before diagnosis.


DOI: 10.1186/s12877-018-0850-z
PubMed: 30021524
PubMed Central: PMC6052670


Affiliations:


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Le document en format XML

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<term>Aged (MeSH)</term>
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<term>Aging (physiology)</term>
<term>Cohort Studies (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hand Strength (physiology)</term>
<term>Humans (MeSH)</term>
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<term>Neoplasms (epidemiology)</term>
<term>Neoplasms (physiopathology)</term>
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<term>Tumeurs (épidémiologie)</term>
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<term>Pays-Bas</term>
<term>Tumeurs</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
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<term>Middle Aged</term>
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<term>Femelle</term>
<term>Humains</term>
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<p>
<b>BACKGROUND</b>
</p>
<p>Impaired physical performance is highly prevalent in older cancer patients and is associated with cancer-related outcomes such as mortality and chemotherapy-related toxicity. Physical performance might already decline prior to the cancer diagnosis due to undiagnosed disease. This study aimed to assess whether the physical performance of community-dwelling individuals prior to cancer diagnosis is worse compared to matched controls who are not diagnosed with cancer.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>The study sample was selected from the Longitudinal Aging Study Amsterdam, a longitudinal study on a nationally representative sample of the Dutch older population. Physical performance of initially cancer-free individuals aged 55-84 years who were diagnosed with cancer during 10 or 20 years of follow-up was compared to the physical performance of controls who were not diagnosed with cancer. For controls, the physical performance measurements of the cycle with a median age closest to the cancer group were used. The time interval between physical performance measurements and the report of cancer was 2 to 4 years. Groups were compared using logistic and linear regression analysis.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>The study sample included 1735 individuals with a median age of 68.7 [interquartile range 63.3-76.4] years. During follow-up, 414 (23.9%) individuals were diagnosed with cancer. Handgrip strength, gait speed, chair stand ability, chair stand test time and ability to put on and take off a cardigan did not differ between groups. Individuals prior to cancer diagnosis were more likely to complete the tandem balance test.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Physical performance of individuals 2 to 4 years prior to report of cancer diagnosis is not lower compared to controls. This suggests that physical performance may not be influenced by cancer before diagnosis.</p>
</div>
</front>
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<DateCompleted>
<Year>2019</Year>
<Month>04</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised>
<Year>2019</Year>
<Month>04</Month>
<Day>25</Day>
</DateRevised>
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<Journal>
<ISSN IssnType="Electronic">1471-2318</ISSN>
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<Volume>18</Volume>
<Issue>1</Issue>
<PubDate>
<Year>2018</Year>
<Month>07</Month>
<Day>18</Day>
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<Title>BMC geriatrics</Title>
<ISOAbbreviation>BMC Geriatr</ISOAbbreviation>
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<ArticleTitle>Do older individuals who are diagnosed with cancer have worse physical performance prior to diagnosis compared to matched controls? A longitudinal cohort study.</ArticleTitle>
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</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12877-018-0850-z</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND">Impaired physical performance is highly prevalent in older cancer patients and is associated with cancer-related outcomes such as mortality and chemotherapy-related toxicity. Physical performance might already decline prior to the cancer diagnosis due to undiagnosed disease. This study aimed to assess whether the physical performance of community-dwelling individuals prior to cancer diagnosis is worse compared to matched controls who are not diagnosed with cancer.</AbstractText>
<AbstractText Label="METHODS">The study sample was selected from the Longitudinal Aging Study Amsterdam, a longitudinal study on a nationally representative sample of the Dutch older population. Physical performance of initially cancer-free individuals aged 55-84 years who were diagnosed with cancer during 10 or 20 years of follow-up was compared to the physical performance of controls who were not diagnosed with cancer. For controls, the physical performance measurements of the cycle with a median age closest to the cancer group were used. The time interval between physical performance measurements and the report of cancer was 2 to 4 years. Groups were compared using logistic and linear regression analysis.</AbstractText>
<AbstractText Label="RESULTS">The study sample included 1735 individuals with a median age of 68.7 [interquartile range 63.3-76.4] years. During follow-up, 414 (23.9%) individuals were diagnosed with cancer. Handgrip strength, gait speed, chair stand ability, chair stand test time and ability to put on and take off a cardigan did not differ between groups. Individuals prior to cancer diagnosis were more likely to complete the tandem balance test.</AbstractText>
<AbstractText Label="CONCLUSIONS">Physical performance of individuals 2 to 4 years prior to report of cancer diagnosis is not lower compared to controls. This suggests that physical performance may not be influenced by cancer before diagnosis.</AbstractText>
</Abstract>
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